TIAFT2006 PROCEEDINGS The International Association of Forensic Toxicologists 44th International meeting TIAFT 2006 27th Aug – 1st Sept 2006 Ljubljana, Slovenia   Organized in co-operation with • TIAFT / www.tiaft.org • FORTOX - Association for Development of Forensic Toxicology and other Forensic Sciences / www.fortox.net • Institute of Forensic medicine, Medical faculty, University of Ljubljana • Slovenian Toxicological Association   Edited by Majda Zorec Karlovšek   Co-edited by FORTOX – Association for Development of Forensic Toxicology and other Forensic Sciences   Published by FORTOX – Association for Development of Forensic Toxicology and other Forensic Sciences   Designed by Luka Mancini / lukatarina.net   Technical support • INFOBIA d.o.o. / www.infobia.net • Birografika BORI d.o.o. / www.birografikabori.si		The TIAFT2006 Proceedings contain a total of 200 contributions, among them 18 in the form of full papers presented at the 44th annual meeting of The International Association of Forensic Toxicologists (TIAFT2006) held in Ljubljana from 27 August to 1 September 2006. Many of papers have been published in peer-reviewed journals: 23 in Forensic Science International, Volume 170, Issue 2/3, pp. 93–216 (6 August 2007) and 3 in the Journal of Chromatography B, Vol. 855, No.2. The Proceedings also include 14 lectures presented at the symposium Medicinal Drugs and Human Performance During the meeting, a roundtable on illegal drugs and traffic safety was arranged. The contributions from different countries were organized according to a questionnaire prepared by chairmen Prof. Olaf Drummer and Prof. Jorg Morland. A summary of these reports, assembled by Prof. Drummer, is also part of the TIAFT2006 proceedings. Some additional contributions highlight the scientific activities and social events during the conference. As editor of this volume, I would like to thank the authors for their contributions and the members of scientific committee for their support, especially in reviewing manuscripts. It was a great pleasure to work with you. Majda Zorec Karlovšek Chair, TIAFT2006 OPENING CEREMONY (OC) PLENARY LECTURES (PL) ROUND TABLE: Illegal Drugs and Traffic Safety ADDITIONAL DOCUMENTS ANALYTICAL METHODS (AM) WORKPLACE DRUG TESTING & DOPING CONTROL (WD) BEHAVIORAL TOXICOLOGY (BT) ALTERNATIVE SPECIMENS (AS) POST-MORTEM TOXICOLOGY (PT) OCCUPATIONAL & ENVIRONMENTAL TOXICOLOGY (OE) CLINICAL FORENSIC TOXICOLOGY (CT) DRUGS OF ABUSE (DA) TOXINS & HERBALS & VENOMS (TH) SYMPOSIUM: Medicinal Drugs and Human Performance TIAFT 2006 Abstract Book (complete) OPENING CEREMONY OC-01 Opening address I Majda Zorec Karlovšek TIAFT2006 Chairperson • Full Text OC-02 Opening address II Dr. Pascal Kintz TIAFT President • Full Text OC-03 Opening address III Prof. Boštjan Žeks President of Slovenian Academy of Sciences and Arts • Full Text - english • Full Text - slovene Top PLENARY LECTURES PL-01 Scopolia Carniolica, J.A.Scopoli, Scopolamine M.Zorec Karlovšek, D.Soban, A.Krbavčič, A.Kobal, Z.Zupanič-Slavec Medical Faculty, Ljubljana, Slovenia • Abstract • Full Text • Presentation PL-02 Scopolamine – its role in clinical and forensic toxicology Hans H. Maurer Department of Experimental and Clinical Toxicology, Saarland University, D-66421 Homburg (Saar) • Abstract PL-03 Orfila and Stas: the fathers of modern toxicology Robert Wennig Laboratoire national de santé, Luxembourg • Abstract PL-04 Advancements in technology for the confirmation of drugs in oral fluid and hair Christine Moore Immunalysis Corporation, Vice President, Toxicology Research and Development, Pomona, CA, USA • Abstract Top ROUND TABLE: Illegal Drugs and Traffic Safety   • Questionnaire.pdf • DUID Summary.xls Top ADDITIONAL DOCUMENTS   • Slovenian Anthem • Fritz Pregl • Professor Machata: letter • TIAFT2006: awards and recognitions Top ANALYTICAL METHODS Platform Presentations - Poster Presentations AM-o-01 Forensic strategy for the detection of plant toxin ricin Yasuo Seto, Mieko Kanamori-Kataoka, Isaac Ohsawa, Kouichiro Tsuge, Takeshi Ohmori, Yasuo Takayama, Yasuo Takayama and Ryoji Sekiokas National Research Institute of Police Science, Kashiwa, Japan, Chiba • Abstract • Full Text AM-o-02 The use of certified reference materials in forensic toxicology Christian Zeine LGC Promochem GmbH, PFC, Wesel, Germany • Abstract AM-o-03 An LC/MS-APCI method for screening and quantification of four fentanyl analogues, atropine and scopolamine in biosamples Agnieszka Skulska1,2 and Maria Kala2 1J. Beyer Faculty of Chemistry, Jagiellonian University, Cracow, Poland; 2 Institute of Forensic Research, Cracow, Poland • Abstract AM-o-04 Detection and validated quantification of the herbal phenalkylamines and methcatinone in human blood plasma by LC-MS-MS J. Beyer1, F.T. Peters1, T. Kraemer2, and H.H. Maurer1 1Department of Experimental and Clinical Toxicology; 2Institute of Legal Medicine, Saarland University, Homburg (Saar), Germany • Abstract AM-o-05 Quantification of basic lipophilic drugs in blood without reference standards by LC-CLND based on extraction recovery estimation Suvi Ojanperä, Soile Tuominen, Ilkka Ojanperä Department of Forensic Medicine, University of Helsinki, Finnland • Abstract AM-o-06 The validation and use of an accredited routine method for the simultaneous analysis of cocaine and two breakdown products in oral fluid by LC-MS-MS Peter Akrill, Claire Reid, Lisa Wilson, Amy Reed, Gail Cooper and Chris Hand Cozart Bioscience Ltd., Abingdon, Oxfordshire, UK • Abstract • Full Text AM-o-07 Microwave assisted acid hydrolysis of urine as a variation of GC-MS based Systematic Toxicological Analysis (STA) L.D. Paul and R.F. Staack Institute of Forensic Medicine, University of Munich, Germany • Abstract AM-o-08 An automated SPE procedure for the simultaneous extraction of the majority of medicinal drugs that affect the mind Diana Kappatos, Stuart Dickson, Sarah Kenworthy, Richard Berezowski, Julie Midgley and Sima Mala Institute of Environmental Science & Research Limited (ESR), New Zealand • Abstract AM-o-09 Determination of Cannabis compounds in blood samples by headspace solid-phase microextraction and gas chromatography-mass spectrometry C.Jurado and M.P.Gimenez Instituto Nacional de Toxicología y Ciencias Forenses, Sevilla,Spain • Abstract AM-o-10 On-line extraction of benzodiazepines using restricted access media and monolithic silica support with a column-switching approach for LC-MS analysis A. Bugey and C. Staub Institute of Forensic Medicine, University of Geneva, Geneva, Switzerland • Abstract AM-o-11 Molecularly imprinted polymer for solid-phase extraction of diazepam and its metabolites from hair samples Marinah M. Ariffin1, Eleanor. I. Miller1, Peter A. G. Cormack2 and Robert A. Anderson1 1University of Glasgow, UK; 2University of Strathclyde, UK • Abstract AM-o-12 An improved method for cyanide determination in blood using solid-phase microextraction and gas chromatography/mass spectrometry Giampietro Frison, Flavio Zancanaro, Donata Favretto and Santo Davide Ferrara Forensic Toxicology and Antidoping, University Hospital of Padova, Padova, Italy • Abstract AM-o-13 LC-ESI-MS-MS determination of ethyl glucuronide and ethyl sulfate in serum Luca Morini, Lucia Politi, Alessandra Zucchella and Aldo Polettini Department of Legal Medicine & Public Health, University of Pavia, Pavia, Italy • Abstract AM-o-14 Unreliable results can always occur unexpectedly, even if an extensive validated method on LC/MS/MS is used Donald R.A.Uges, Jan-Pieter Thie and Ben Greijdanus Laboratory for Clinical and Forensic Drug Monitoring and Toxicology, University Medical Center Groningen, The Netherlands • Abstract AM-o-15 Direct detection of methamphetamine and MDMA in human urine by APCI-Ion Trap Mass Spectrometry Naohito Uetake1, Noriyuki Tachi1, Hiroyuki Inoue2, Yuko T. Iwata2, Tatsuyuki Kanamori2, Hajime Miyaguchi2, Kenji Tsujikawa2, Kenji Kuwayama2 and Tohru Kishi2 1Hitachi Ltd., 2National Research Institute of Police Science, Japan • Abstract AM-o-16 Detection of benzodiazepines in hair by ELISA and LC-ESI-MS-MS Eleanor Isabel Miller, Fiona Mary Wylie and John Samuel Oliver University of Glasgow, Scotland • Abstract AM-o-17 Determination of a designer drug 1-(3-chlorophenyl)piperazine (mCPP) and its parent compound trazodone in hair by High-Performance Liquid Chromatography–Electrospray Mass Spectrometry (HPLC–ESI-MS) Roman Stanaszek and Wojciech Lechowicz Institute of Forensic Research, Cracow, Poland • Abstract Top ANALYTICAL METHODS Poster Presentations - Platform Presentations AM-p-01 Specific screening for illegal drugs and psychoactive medicines in whole blood using LC/MS/MS Asbjørg S. Christophersen, Unni Johansen and Elisabeth Leere Øiestad Division of Forensic Toxicology and Drugs Abuse, Norwegian Institute of Public Health P.O. Box 4404 Nydalen, 0443 Oslo Norway • Abstract AM-p-02 Analysis of THC, 11-OH-THC, THC-COOH, CBD and CBN by Liquid Chromatography-tandem Mass Spectrometry in human EDTA-plasma and urine after small doses of THC and Cannabis Sativa extract Sandra Grauwiler1, André Scholer2, Jürgen Drewe3 1University Hospital Basel, Clinical Chemistry Laboratory, Petersgraben 4,CH-4031 Basel; 2Laboratory Medicine, Clinical Chemistry Laboratory, Petersgraben 4, CH-4031 Basel; 3Division of Clinical Pharmacology and Toxicology, University Hospital Basel, CH-4031 Basel • Abstract AM-p-03 Detection and analysis of cannabinoids in bio-samples by Surface-Ionization methods U. Khasanov1, U.Kh.Rasulev1, D.T.Usmanov1, S.S.Iskhakova1, R.K.Akhmedova2 1Arifov Institute of Electronics, Uzbek Academy of Sciences, Akademgorodok, 33 F.Hojaev str., 700125 Tashkent, Uzbekistan; 2Republican Center of Forensic Expertise, Tashkent, Uzbekistan • Abstract AM-p-04 Validated method for the determination of ∆9-tetrahydrocannabinol (THC), 11-hydroxy-∆9-THC and 11-nor-9-carboxy-∆9-THC in oral fluid, urine and blood using solid-phase extraction and liquid chromatography- mass spectrometry with electrospray ionization H.M. Teixeira1,2, A. Verstraete3, P. Proença1, F. Corte-Real1,2, P.V. Monsanto1, D.N. Vieira12 1Medicine, Coimbra, Portugal; 2Faculty of Medicine, Coimbra University, Coimbra, Portugal; 3Laboratory of Clinical Biology-Toxicology, Ghent University Hospital, Ghent, Belgium • Abstract AM-p-05 The impurity characteristics of methamphetamine synthesized by Emde and Nagai method Beom Jun Ko1, SungIll Suh1, Yong Jun Suh1, Moon Kyo In1, Sung-Hong Kim3 1Drug Signature Analysis Center, Supreme Prosecutors’ Office, Seoul 137-730, Korea; 2School of Agricultural Biotechnology, Seoul National University, San 56-1, Sillim-Dong, Gwanak-gu, Seoul, 151-742, Korea; 3Korea Basic Science Institute, Daegu branch, 1370, Sankyuk-Dong, Puk-gu, Daegu, 702-701, Korea • Abstract AM-p-06 Determination of ibotenic acid and muscimol in Amanita mushrooms and rat plasma by HPLC-UV and LC/MS Kenji Tsujikawa1 , Kenji Kuwayama1, Hajime Miyaguchi1, Tatsuyuki Kanamori1, Yuko Iwata1, Hiroyuki Inoue1, Takemi Yoshida2, Tohru Kishi1 1National Research Institute of Police Science, 6-3-1, Kashiwanoha, 277-0882, Kashiwa, Japan, Chiba; 2Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University • Abstract AM-p-07 Systematic toxicological analysis of xenobiotics – The LC/MS approach L. Humbert1, M. Roberts2, M. Wood2, G.Bondoux3, M. Lhermitte1 1Laboratoire de Toxicologie & Génopathies, Hôpital Calmette - CHRU de Lille, 59037 Lille Cedex - France; 2Waters Corporation Atlas Park, Simonsway, Manchester M22 5PP - UK; 3Waters Corporation European Headquarters Waters S.A.S. 78280 Guyancourt - France • Abstract AM-p-08 LC-MS/MS determination of urinary 5-hydroxytryptophol glucuronide and 5-hydroxyindole-3-acetic acid Nikolai Stephanson1, Olof Beck1 and Anders Helander2 1Department of Clinical Pharmacology; 2Department of Clinical Neuroscience, Karolinska Hospital & Institute, Stockholm, Sweden • Abstract AM-p-09 Benzodiazepine detection in hair by MISPE v. SPE Marinah M. Ariffin1, Eleanor I. Miller1, Peter A. G.Cormack2 and Robert A. Anderson1 1University of Glasgow, UK; 1University of Strathclyde, UK • Abstract AM-p-10 Screening by immunoassay and confirmation & quantitation by GC-MS of buprenorphine and norbuprenorphine in urine, whole blood and serum Nina Kangas, Sirpa Mykkänen, Sanna Kyllönen, Päivi Rajala, Kari Ariniemi and Pirjo Lillsunde Laboratory of Alcohol and Substance Abuse, Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland • Abstract • Full Text AM-p-11 Simultaneous determination of newer anti-epileptic drugs (AEDs) by liquid chromatography mass spectrometry (LC-MS) Chyh Yeng Tan, Eugene Wee Sing Goh, Hsiao Tung Leong, Dr Yi Ju Yao and Dr Danny Siaw Teck Lo Toxicology Laboratory, Center for Forensic Science, Health Sciences Authority, 11 Outram Road, Singapore • Abstract AM-p-12 Screening of basic drugs in urine by GC-NPD, GC-MS and HPLC-DAD: automation and comparison of solid phase extraction columns Helene B. Klinke, Suzanne Nielsen Dept. of Forensic Chemistry, Institute of Forensic Medicine, University of Copenhagen, Denmark • Abstract AM-p-13 CZE-ESI-TOF MS applied to hair analysis in the screening for drugs of abuse Rossella Gottardo, Ameriga Fanigliulo, Jennifer P. Pascali, Franco Tagliaro Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, Verona, Italy • Abstract AM-p-14 New automated technique for the simultaneous detection of some addictive drugs in saliva samples with the Fast GC/MS SPME Multifiber System Gagliano-Candela R.1, Strisciullo G.1, Dugheri S.2, Pacenti M.2, Degli Esposti F.3, Arcangeli G.2, Cupelli V.2 1Forensic Toxicology Chair, Department of Internal Medicine and Public Health,University of Bari, P.za G Cesare, 11-70124 Bari, Italy; 2Occupational Medicine Division, Department of Public Health, University of Florence, Largo Palagi, 1- 50134 Florence, Italy; 3ChromLine Srl, Via Anita Garibaldi, 40 -59100 Prato, Italy • Abstract AM-p-15 Determination of gamma-hydroxybutyric acid (GHB) and its precursors in blood and urine samples: salting- out approach A. Kankaanpää, R. Liukkonen and K. Ariniemi Drug Research Unit, Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland • Abstract AM-p-16 Detection, confirmation, and quantitation of several drugs of abuse in urine using LC/MS/MS Tania A. Sasaki1, Robert Galvin2, Daniel Blake2, Bénédicte Duretz3 1Applied Biosystems Foster City, CA USA; 2Applied Biosystems, Warrington, England; 3Applied Biosystems, Les Ulis, France • Abstract AM-p-17 Method validation for the simultaneous analysis of organophosphate pesticides in blood by GC/MS Mee Jung Park, Sang Ki Lee, Ja Youl Yang, Ki Wook Kim, Sang Whan In, You Sin Park, Hee Sun Chung, Young Chan Yoo National Institute of Scientific Investigation, Seoul 158-707, Korea • Abstract AM-p-18 Fast and efficient measurement of the short term alcohol marker 5-hydroxytryptophol / 5-hydroxyindolic acid in urine with RP-HPLC and fluorescence detection Lydia Halwachs, Rainer W. Schmid Medical & Chemical Labdiagnostics, University Hospital Vienna, Medical University of Vienna, Austria • Abstract AM-p-19 Method validation of cyanide quantification in blood Ki Wook Kim, Sang Ki Lee, Ja Youl Yang, Mee Jung Park, Sang Whan In, You Sin Park, Hee Sun Chung, Young Chan Yoo National Institute of Scientific Investigation, Seoul 158-707, Korea • Abstract AM-p-20 Simultaneous extraction of alkaline addictive drugs from post-mortem human adipose tissues and GC/MS detection Perkins de Piacentino A.M.1, Gagliano-Candela R.2, Aventaggiato L.2, Colucci A.P2 1Laboratorio de Toxicologia y Quimica Legal, Cuerpo Medico Forense, Corte Suprema de Justicia de la Nacion, Viamonte 2151, C1056ABG Buenos Aires, Argentina; 2Forensic Toxicology Chair, Department of Internal Medicine and Public Health, University of Bari, P.za G. Cesare 11 – 70124 Bari, Italy • Abstract AM-p-21 A high-throughput on-line SPE-LC-MS/MS method for the analysis of 14 antidepressants and metabolites in plasma A. de Castro2, M.M. Ramírez1, M.Laloup1, N. Samyn1, G. De Boeck1, M. López-Rivadulla2 1Toxicology Section. National Institute of Criminalistics and Criminology, Brussels, Belgium; 2Forensic Toxicology Service, Institute of Legal Medicine, University of Santiago of Compostela, Spain • Abstract AM-p-22 Glass catalysed conversion of candesartan cilexetil to the active metabolite candesartan and its alkylated derivates Nerea Ferreirós, Sebastian Dresen, Volker Auwaerter, Wolfgang Weinmann Institute of Forensic Medicine, University Hospital Freiburg, Albertstr. 9, D 79104 Freiburg, Germany • Abstract AM-p-23 Analysis of urine organic acids using Linear Retention Indices for the determination of inherited metabolic disorders Margit Geissler1, Shuichi Kawana2 1Shimadzu Europa GmbH, Duisburg, Germany; 2Shimadzu Corporation, Kyoto, Japan • Abstract AM-p-24 Development of a Multiplex Toxicology Panel of Immunoassays William Link, Renato del Rosario, Joel Hardy, David King, Raisa Lerner, Randy Sweet, and Kunquan Yao Bio-Rad Laboratories Inc, Hercules, CA 94547, USA • Abstract AM-p-25 Identification of anabolic agent abuse in sport: determination of androgen glucuro- and sulfoconjugates in urine by LC-MS/MS Susanna Vogliardi, Mariela Ivanova Marinova, Donata Favretto, Flavio Zancanaro, Santo Davide Ferrara Forensic Toxicology and Antidoping, University Hospital of Padova, Via Falloppio 50, I-35121 Padova, Italy • Abstract AM-p-26 A method using an analyte trapping reagent, for the simultaneous analysis of the amino urinary metabolites of flunitrazepam, clonazepam and nitrazepam, by GC-MS R.A.F. Couch and H.Madhavaram LabPlus, Auckland City Hospital, Auckland, New Zealand • Abstract AM-p-27 High throughput extraction of drugs from biological fluids using an improved supported liquid extraction plate Richard Calverley, Lee Williams, Scott Merriman, Helen Lodder, Anne Howells, Steve Jordan, Claire Desbrow, Matthew Cleeve Argonaut Technologies, now a Biotage company, New Road, Hengoed, Mid Glamorgan, CF82 8AU, UK • Abstract AM-p-28 Analysis of inorganic impurities in illicit methamphetamine using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) SungIll Suh1, Beom Jun Ko12, Yong Jun Suh1, Moon Kyo In1 and Sung-Hong Kim3 1Drug Signature Analysis Center, Supreme Prosecutors' Office, Seoul 137-730, Korea; 2School of Agricultural Biotechnology, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, Seoul, 151-742, Korea; 3Korea Basic Science Institute, Daegu branch, 1370, Sankyuk-dong, Puk-gu, Daegu, 702-701, Korea • Abstract AM-p-29 HPLC-ESI-MS/MS in bioanalytical chromatography: Can we forget chromatography? Rainer W. Schmid and Lydia Halwachs Medical & Chemical Labdiagnostics, University Hospital Vienna, Medical University of Vienna, Austria • Abstract Top WORKPLACE DRUG TESTING & DOPING CONTROL Platform Presentations - Poster Presentations WD-o-01 Psychotropic Side-Effects of Anabolic Steroids CM Müller-Platz1, RK Müller2, H. Michna3 1Federal Institute of Sports Science, Bonn; 2Institute of Doping Analysis and Sportsbiochemistry, Dresden; 3Institute of Public Health Research, Technical University Munich, Germany • Abstract WD-o-02 Analysis of Anabolic Steroids in Urine by LC/MS/MS Michael C. Zumwalt1, John M. Hughes1, Matthew H. Slawson2, Chad R. Borges2 and Dennis J. Crouch2 1Agilent Technologies, Englewood, MS; 2Center for Human Toxicology, University of Utah, USA • Abstract WD-o-03 Determination of Opiates, Amphetamines, Cocaine, Phencyclidine, and Metabolites in Hair by LC-MS-MS Min-Kun Huang, Choung-Huei Lee, Chiareiy Liu, Chun-Sheng Chien National Bureau of Controlled Drugs, DOH, Taiwan, ROC • Abstract WD-o-04 Overview of the situation of workplace drug testing in Europe Alain G Verstraete Laboratory of Clinical Biology–Toxicology, Ghent University Hospital, and Department of Clinical Biology, Microbiology and Immunology, Ghent University, Belgium • Abstract WD-o-05 WORKPLACE DRUG TESTING: THREE YEARS EXPERIENCE IN THE FINNISH DEFENSE FORCES Sirpa Mykkänen1, Pirjo Lillsunde1, Esa Meririnne2, Kyösti Lehtomäki2, Markus Henriksson1 1National Public Health Institute, Laboratory of Alcohol and Substance Abuse, Helsinki, Finland; 2Centre for Military Medicine, Finnish Defense Forces, Lahti, Finland • Abstract WD-o-06 Presence of THC-COOH in urine after drinking "Cannabis-beer" Olof M.L.Beck1, Mats Brunes2, Michael Boettcher3 1Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden; 2Dependence Clinic, Karolinska Hospital, Stockholm, Sweden; 3Arxtpraxis f. Med. Mikrobiol., Dessau, Germany • Abstract Top WORKPLACE DRUG TESTING & DOPING CONTROL Poster Presentations - Platform Presentations WD-p-01 Preliminary investigations of diuretic screening method converted from HPLC/MS to UPLC/MS Russell Watts1, Philip Grace2, Michelle Wood1 and Simon Hudson2 1Waters Corporation, MS Technologies Centre, Manchester, UK; 2HFL, Fordham, Cambridgeshire, UK • Abstract WD-p-02 Methylnoretiocholanolone Sulfate – Long-Term Metabolite of Methylnortestosterone (17Α-Methylnandrolone) Victor P. Uralets, Stacy A. Sweeney Quest Diagnostics, 4230 Burnham Avenue, Las Vegas, Nevada 89119, USA • Abstract WD-p-03 Characterization of the Metabolites of New Designer Anabolic Steroids Grigory Rodchenkov, Tim Sobolevsky and Vladimir Sizoi Antidoping Centre, Elizavetinsky per.10, 105005, Moscow, Russia • Abstract WD-p-04 Metabolism of Non-Steroidal Phytoestrogens: Ipriflavone and 5-Methyl-isoflavones Svetlana Appolonova*, Pavel Baranov, Grigory Rodchenkov Antidoping Centre, Elizavetinsky per.10, 105005, Moscow, Russia • Abstract • Full Text WD-p-05 Excretion Study of Methylprednisolone using HPLC-MS Ion Trap Marina Dikunets, Svetlana Appolonova, Grigory Rodchenkov Antidoping Centre, Elizavetinsky per.10, 105005, Moscow, Russia • Abstract • Full Text WD-p-06 SPE-LC-TOFMS screening method for detection of doping agents in urine M. Kolmonena1,2, A. Pelandera1, A. Leinonen2, I. Ojanperäa1 1Forensic Toxicology Division, Department of Forensic Medicine, University of Helsinki, Finland; 2Doping Control Laboratory, United Laboratories Ltd., Helsinki, Finland • Abstract Top BEHAVIORAL TOXICOLOGY Platform Presentations - Poster Presentations BT-o-01 Prevalence of alcohol and illegal drugs in blood samples from drivers involved in traffic law violations: systematic review of the literature Leonardo González Wilhelm1,2 1Center of Forensic Medicine, J.W. Goethe University, Frankfurt/Main, Germany; 2CIGES (Center of Training, Research and Management for Evidence-Based Health), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile • Abstract BT-o-02 Cannabis and driving: results from a general population survey F. Javier Álvarez, Inmaculada Fierro and M. Carmen del Río Department of Pharmacology, Institute for Alcohol and Drug Studies, Faculty of Medicine, University of Valladolid, Spain • Abstract BT-o-03 Application of models for the prediction of time of marijuana exposure from blood of drivers arrested for DUI Ann Marie Gordon, Rodney Gullberg and Barry K. Logan Washington State Toxicology Laboratory, Seattle, WA, USA • Abstract BT-o-04 Age- and sex-related differences in blood- amphetamine concentrations in DUID suspects and reflections on drug- related impairment Alan Wayne Jones Department of Forensic Chemistry, Linköping, Sweden • Abstract BT-o-05 Driving Impairment from Dextromethorphan Abuse Barry K. Logan1 and Chuck Hayes2 1Washington State Toxicology Laboratory, Seattle, WA, USA; 2IACP/DRE, Salem, OR, USA • Abstract BT-o-06 Risk of involvement in traffic accidents associated with the prescription of medicinal drugs: A registry-based cohort study J. Mørland, S. Skurtveit and A. Engeland Norwegian Institute of Public health, Oslo, Norway • Abstract Top BEHAVIORAL TOXICOLOGY Poster Presentations - Platform Presentations BT-p-01 Mescaline effects on rat’s behaviour and the time profile of mescaline in rat serum and brain tissue after a single subcutaneous dose using GC-MS T. Páleníček1, M. A. Balíková2 1Prague Psychiatric Center, Ústavní 91, 181 03 Prague 8 -Bohnice; 2Institute of Forensic Medicine and Toxicology, 1st Medical Faculty, Charles University in Prague, 121 08 Prague 2 • Abstract BT-p-02 Concurrent measurements of arterial and venous blood alcohol concentrations and breath alcohol concentrations using the alcotest 7110 MK III Evidential Katja Jachau, Holger Wittig, Dieter Krause Institute of Forensic Medicine, Otto-von-Guericke University Magdeburg, Germany • Abstract • Full Text BT-p-03 Determination of CDT. Comparison of ion exchange columns chromatography and capillary electrophoresis Petra Finderle, Živa Flisar, Marija Prezelj University Medical Centre Ljubljana, Institute of Clinical Chemistry and Biochemistry, Njegoševa 4, 1525 Ljubljana, Slovenia • Abstract BT-p-04 Effect of acetaldehyde on dopamine and dopamine-derived salsolinol in the brain of free-moving rats using in vivo Reverse Microdialysis Technique Kiyoshi Ameno, Weihuan Wang, Mostofa Jamal, Mitsuru Kumihashi, Ikuo Uekita, and Iwao Ijiri Department of Forensic Medicine, Kagawa University, Kagawa 761-0793, Japan • Abstract BT-p-05 Prevalence of alcohol and illegal drugs in blood samples from adults involved in traffic law violations in the area of Frankfurt/Main (Germany) Leonardo González Wilhelm1,2, Juan José Orellana2, Gerold Kauert1, Hansjürgen Bratzke1 1Center of Forensic Medicine, J.W. Goethe University, Frankfurt/Main, Germany; 2CIGES (Center of Training, Research and Management for Evidence-Based Health), Faculty of Medicine, Universidad de La Frontera, Temuco, Chile • Abstract Top ALTERNATIVE SPECIMENS Platform Presentations - Poster Presentations AS-o-01 Drugs in oral fluid in randomly selected drivers Olaf H. Drummer, D. Gerostamoulos and M. Chu Forensic and Scientific Services, Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Melbourne, Australia • Abstract AS-o-02 Analysis of paired blood and oral fluid specimens from randomly selected nighttime drivers Christine Moore1, John Lacey2 , Tara Kelley-Baker2, Cynthia Coulter1, Katharine Brainard2 , Debra Furr-Holden2, Sumandeep Rana1 and Michael Vincent1 1Immunalysis Corporation, 829 Towne Center Drive, Pomona, California 91767; 2Pacific Institute for Research & Evaluation, 11710 Beltsville Drive, Calverton, Maryland, 20705,USA • Abstract AS-o-03 Roadside drug testing in oral fluid – the Saarland experience Thomas Kraemer1, Katrin Ettmueller1, Eva Prinz1, Hans-Juergen Maurer2 and Jochen Wilske1 1Institute of Legal Medicine, Saarland University, Homburg, Germany; 2Saarland State Police Department, Saarbruecken, Germany • Abstract AS-o-04 Confirmation by LC-MS of drugs in oral fluid obtained from Roadside testing M. Concheiro, A. de Castro, O. Quintela, A. Cruz and M. López-Rivadulla. Forensic Toxicology Service. Institute of Legal Medicine. University of Santiago of Compostela. Spain • Abstract AS-o-05 Use of oral fluid drug tests at the roadside: the results of the Rosita-2 study A.Verstraete1, E. Raes2 1Laboratory of Clinical Biology–Toxicology, Ghent University Hospital; 2Department of Clinical Biology, Microbiology and Immunology, Ghent University, Belgium • Abstract AS-o-06 An evaluation of five rapid oral fluid drug-testing devices Maria Kala, Wojciech Lechowicz, Piotr Adamowicz, Ewa Chudzikiewicz, Ewa Janowska and Maciej Kochanowski Institute of Forensic Research in Krakow, Poland • Abstract AS-o-07 Development and validation of the Cozart® DDS Oral Fluid Collection Device T. Speedy, D. Baldwin, G. Jowett, M. Gallina and A. Jehanli Cozart Bioscience Ltd, Abingdon, Oxfordshire, England • Abstract AS-o-08 The recovery of illicit drugs from oral fluid sampling devices Susan Nolan Institute of Environmental Science and Research Limited, New Zealand • Abstract AS-o-09 Simultaneous determination of 6 amphetamines and analogues in hair and urine by LC-ESI-MS/MS: Application to the determination of MDMA after the absorption of a single dose of “Ecstasy” M. Chèze, M. Deveaux and G. Pépin Laboratoire TOXLAB, Paris, France • Abstract AS-o-10 Detection of diazepam in urine, hair and preserved oral fluid samples with LC-MS-MS after single and repeated administration of Myolastan® and Valium® Marleen Laloup1, Maria del Mar Ramirez Fernandez1, Michelle Wood2, Gert De Boeck1, Viviane Maes3, Nele Samyn1 1National Institute of Criminalistics and Criminology; 2Waters Corporation; 3Academic Hospital AZ-VUB, Belgium • Abstract AS-o-11 Applications of arsenic speciation by HPLC-ICP/MS P. Kintz, N. Marques, M. Ginet and V. Cirimele Laboratoire ChemTox, Illkirch, France • Abstract AS-o-12 Ecstasy (MDMA) detected in 3 years old semen stains in a case of sexual assault Peter X. Iten and Maja Zaugg Institute of Legal Medicine, Dept. of Forensic Toxicology, Zurich, Switzerland • Abstract Top ALTERNATIVE SPECIMENS Poster Presentations - Platform Presentations AS-p-01 The disposition into hair of a new designer drug, methylone and its related compounds Ruri Kikura-Hanajiri National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya, 158-8501, Tokyo, Japan • Abstract AS-p-02 Determination of opioid analgesics in hair samples of patients under palliative care F. Musshoff1, K. Lachenmeier1, U.Stamer2, F.F. Nauck3, B. Madea1 1Institute of Legal Medicine, Stiftsplatz 12, 53111 Bonn, Germany; 2Clinic of Anaesthesiology an Operative Intensive Care Medicine, University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany; 3Centre of Palliative Medicine, Malteser Hospital Bonn, Von-Hompesch-Straße 1, 53123 Bonn, Germany • Abstract AS-p-03 Patterns in drug use in the United Kingdom as revealed through analysis of hair in a large population sample Lolita Tsanaclis, John Wicks Tricho-Tech Limited, UK • Abstract AS-p-04 Evaluation of the IDS ONE-STEP&tm; Elisa kit for the detection of illicit drugs in hair specimens versus GC/MS V Cirimele, ML Pujol, PJ Tritsch, M Villain, P Kintz Laboratoire ChemTox, F-67400 Illkirch, France • Abstract AS-p-05 Routine drug of abuse monitoring in saliva with a new collection procedure and a modified homogenous immunoassays Bettina Tuerk1,2, Dietmar Leichtfried2, Lydia Halwachs1, Rainer W. Schmid1 1Medical & Chemical Labdiagnostics, University Hospital Vienna, Medical University of Vienna, Austria; 2Greiner Bio-One, Kremsmuenster, Austria • Abstract AS-p-06 Method development and validation for analysis of amphetamine, methamphetamine, methylenedioxy derivatives and metabolites in sweat patches using disk solid-phase extraction and gas chromatography-mass spectrometry Bruno S. De Martinis1, Allan J. Barnes2, Karl B. Scheidweiler2 and Marilyn A. Huestis2* 1Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Center of Legal Medicine, Ribeirão Preto, SP, 14051-140, Brazil; 2Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr., Baltimore, MD 21224, USA • Abstract Top POST-MORTEM TOXICOLOGY Platform Presentations - Poster Presentations PT-o-01 Postmortem cases involving amphetamine-based drugs in the Netherlands Miranda Verschraagen, Ann Maes, Bart Ruiter, Ingrid J. Bosman, Beitske E. Smink and Klaas J. Lusthof Netherlands Forensic Institute, Department of Pathology and Toxicology, The Hague, The Netherlands • Abstract PT-o-02 Reference postmortem concentrations of antidepressant drugs reflected in a therapeutic material. Margareta Reis1, Trond Aamo2, Johan Ahlner3 and Henrik Druid4 1Dept of Clinical Pharmacology, Linköping University Sweden; 2Dept of Clinical Pharmacology, Trondheim University Hospital, Norway; 3Dept of Forensic Chemistry, National Board of Forensic Medicine, Linköping, Sweden; 4Dept of Forensic Medicine, Karolinska Institute, Stockholm, Sweden • Abstract PT-o-03 Liquid chromatography-multiple mass spectrometry determination of atracurium and laudanosine in a case of suspected multi-homicide Donata Favretto, Mariela Ivanova, Alessandro Nalesso, Franca Castagna and Santo Davide Ferrara Forensic Toxicology and Antidoping, University Hospital of Padova, Padova, Italy • Abstract PT-o-04 Analytical toxicology of 3-methylfentanyl related deaths Ilkka Ojanperä1, Merja Gergov1, Milana Liiv2, Aime Riikoja2 and Erkki Vuori1 1Department of Forensic Medicine, University of Helsinki, Finland, 2Estonian Bureau of Forensic Medicine, Tallinn, Estonia • Abstract PT-o-05 Postmortem redistribution of cannabinoids: first results of a study performed in a pig model B. Brunet1,2, F. Favreau13, T. Hauet13, W. Hebrard4, Y. Papet2, G. Mauco13, P. Mura2 1INSERM E-0324, Poitiers, France; 2Centre hospitalier universitaire Laboratoire de toxicologie et pharmacocinétique, Poitiers, France; 3Centre hospitalier universitaire Laboratoire de Biochimie, Poitiers, France; 4INRA, GEPA Laboratoire de chirurgie expérimentale, Surgères, France • Abstract PT-o-06 A study of multiple-drug suicides involving oxycodone M. Deveaux and G. Pépin Laboratoire TOXLAB, F-75018 Paris, France • Abstract PT-o-07 Fatal intoxication by butenes: HS-GC/FID and HS-GC/MS determination of butene isomers in bio-fluids and tissues Alessandro Nalesso, Donata Favretto, Claudio Terranova, Sergio Maietti, Santo Davide Ferrara Forensic Toxicology and Antidoping, University Hospital of Padova, Padova, Italy • Abstract PT-o-08 Ethyl glucuronide in blood as a marker of ante-mortem ingestion of alcohol; possibility of false negative results G.Høiseth, R.Karinen, A.Christophersen, L.Johnsen, P.T.Normann and J.Mørland Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway • Abstract PT-o-09 Analysis of 2,4-dinitrophenol and its phase I and phase II metabolites in a case of fatal poisoning using a 4000 QTrap LC-MS-MS system Lucia Politi, Claudia Vignali and Aldo Polettini Department of Legal Medicine & Public Health, University of Pavia, Italy • Abstract PT-o-10 Accidental death following inadvertent perfusion of zinc oxide shake lotion Fritz Pragst, Andreas Correns, Friedrich Priem, Sieglinde Herre and Hubert Martin Institute of Legal Medicine, University Hospital Charité, Berlin, Germany • Abstract PT-o-11 Fatality involving vinblastine overdose as a result of a complex medical error Małgorzata Kłys, Tomasz Konopka, Mariusz Ścisłowski, Piotr Kowalski Department of Toxicology, Institute of Forensic Medicine, Collegium Medicum, Jagiellonian University, Krakow, Poland • Abstract Top POST-MORTEM TOXICOLOGY Poster Presentations - Platform Presentations PT-p-01 Suicidal inhalation of motorbike exhaust: adding new data to the literature about the contribution of gasoline to the cause of death María A. Martínez1 and Salomé Ballesteros2 1Chemistry Department; 2Spanish Poison Control Center, National Institute of Toxicology and Forensic Sciences, Ministry of Justice, C/ Luis Cabrera 9, 28002 Madrid, Spain • Abstract PT-p-02 A fatal intoxication with the antimalarial drug chloroquine Nicolas Vrydags1, Kathleen Croes1, Jan Bolt2 and Frank Martens1 1Department of Forensic Toxicology, AZ Groeninge, Kortrijk, Belgium; 2Forensic pathologist, Kruishoutem, Belgium • Abstract PT-p-03 Fatal case at a workplace involving fluosilicate of zinc Teresa Lech Institute of Forensic Research, 31-033 Krakow, Poland • Abstract • Full Text PT-p-04 The value of brain specimens in post-mortem forensic toxicology Thomas Stimpfl and Sabine Reichel Department of Forensic Medicine, Medical University of Vienna, Sensengasse 2, A-1090 Vienna, Austria • Abstract PT-p-05 A novel protocol for the analysis of diltiazem to aid interpretation Simon Elliott, Collin Seneviratne Regional Laboratory for Toxicology, City Hospital, Birmingham, UK • Abstract PT-p-06 Levamisole as a contaminant of illicit Cocaine Morley S.R., Forrest A.R.W. , Galloway J.H. Toxicology Section, Sheffield Teaching Hospital Foundation Trust, Sheffield, S10 2JF, United Kingdom • Abstract PT-p-07 Zolpidem in lethal cases Marie Staňková, Petr Kurka Institute of Forensic Medicine, University Hospital Ostrava, Czech Republic • Abstract • Full Text PT-p-08 Rapid determination of methadone in postmortem whole blood and cerebellum Birgit Reiter Department of Forensic Medicine , Sensengasse 2, A-1090 Vienna, Austria • Abstract • Full Text PT-p-09 A comparative study on the production of ethyl and methyl alcohol in post mortem specimens (blood, brain tissue and muscle) I. A. Alabdooli1, F.A. Tarbah1, F.A. Benomran1 and Th. Daldrup2 1Dubai Police H.Q. Forensic Science Dept. P.O. Box 1493, Dubai, U.A.E; 2Institute of Legal Medicine, Heinrich-Heine-University, Duesseldorf, Germany • Abstract • Full Text PT-p-10 Analysis of paraquat in post-mortem specimens of a paraquat-related death by HPLC Chyh Yeng Tan, Hsiao Tung Leong, Tian Hwee Koh, Eugene W. S. Goh, Yi Ju Yao, Danny S.T. Lo Toxicology Laboratory, Centre for Forensic Science, Health Sciences Authority, 11 Outram Road, Singapore • Abstract PT-p-11 Postmortem femoral blood concentrations of opiates Fredrik C. Kugelberg, Henrik Druid Department of Forensic Medicine, Karolinska Institutet, Stockholm, Sweden, and The National Board of Forensic Medicine, Linköping, Sweden • Abstract PT-p-12 Distribution of dimethoate in the body after a fatal organophosphate intoxication F. A. Tarbah1, F.A. Benomran1, A. I. Hassan1, A.M. Shaheen1 and Th. Daldrup2 1Dubai Police H.Q, Forensic Science Dept. P.O. Box 1493, Dubai, U.A.E; 2Institute of Legal Medicine, Heinrich-Heine-University, Duesseldorf, Germany • Abstract PT-p-13 Toxicological analysis after asphyxial suicide with helium and a plastic bag V. Auwärter, M. Große Perdekamp, J. Kempf, W. Weinmann, U. Schmidt, S. Pollak Institute of Legal Medicine, University Hospital Freiburg • Abstract PT-p-14 Nefopam Fatality Julie Elizabeth Midgley, Helen Poulsen Institute of Environmental Science and Research, PO Box 50-348, Porirua, New Zealand • Abstract PT-p-15 Fatal single-vehicle chrash under the influence of ketamine and alcohol Y Barguil1, M Deveaux2, S Mermond1, M Chèze1, E Choblet1, G Pépin2 1Biochemistry Laboratory, New Caledonia Territorial Hospital, 98849 Noumea, New Caledonia; 2Laboratoire TOXLAB, F-75018 Paris, France • Abstract PT-p-16 A database for forensic toxicology available via Internet. Johan Ahlner1, Margareta Reis2, Henrik Druid3 1Dept of Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden; 2Dept of Clinical Pharmacology, Linköping University, Sweden; 3Dept of Forensic Medicine, Karolinska Institute, Stockholm, Sweden • Abstract PT-p-17 Method for Quantification of Opioids and their Metabolites in Autopsy Blood by Liquid Chromatography-Tandem Mass Spectrometry Ahmed I. Al-Asmari and Robert A. Anderson University of Glasgow, UK • Abstract PT-p-18 A case report: Tianeptine (STABLON®) related death P. Proença1, H.M. Teixeira1,2, J.Pinheiro1, A. Claro1, P.V. Monsanto1, D.N. Vieira1,2 1National Institute of Legal Medicine, Coimbra, Portugal; 2Faculty of Medicine, Coimbra University, Coimbra, Portugal • Abstract PT-p-19 Determination and distribution of clotiapine (Entumine®) in human plasma, postmortem blood and tissue samples from clotiapine treated patients and from autopsy cases Frank Sporkert1, Marc Augsburger1, Christian Giroud1, Clarisse Brossard1, Chin B. Eap2 and Patrice Mangin1 1Institut Universitaire de Médecine Légale, Rue du Bugnon 21, CH-1005 Lausanne, Switzerland; 2Unité de Biochimie et Psychopharmacologie Clinique, Département Universitaire de Psychiatrie Adulte et • Abstract Top OCCUPATIONAL & ENVIRONMENTAL TOXICOLOGY Platform Presentations - Poster Presentations OE-o-01 Microcystis Aeruginosa and microcistyns in the Rio de la Plata L. Giannuzzi1, D.Andrinolo1, M. Caneo1, M. Di Lorenzo1, R.Echenique2, M.Barco3, J.Rivera3 and J.Caixach1 1Cátedra de Toxicología y Química Legal Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), La Plata, Argentina; 2Departamento de Ficología, Facultad de Ciencias Naturales y Museo. UNL; 3Laboratorio de Espectrometria de Masas, Departamento de Ecotecnología , Barcelona , España • Abstract OE-o-02 Mercury Impact on the Health of Miners in the Idrija Mercury Mine after the Second World War Alfred Bogomir Kobal Department of Occupational Medicine, Idrija Mercury Mine, Idrija, Slovenia • Abstract Top OCCUPATIONAL & ENVIRONMENTAL TOXICOLOGY Poster Presentations - Platform Presentations OE-p-01 Glutathione and mercury conjugate with glutathione in ex-miners' erythrocytes Marija Prezelj1, Mladen Krsnik1, Milena Horvat2, Alfred B. Kobal1 1Clinical Institute of Clinical Chemistry and Biochemistry, Medical Centre Ljubljana, Slovenia; 2J.Stefan Institute, Jamova 39, Ljubljana, Slovenia • Abstract OE-p-02 Pineal hormone melatonin level in ex-mercury miners Joško Osredkar1, Milena Horvat2, Mladen Krsnik1, Darja Kobal3, Bernard Ženko2, Sašo Džeroski2 and Alfred B. Kobal1 1Clinical Institute of Clinical Chemistry and Biochemistry, Medical Centre Ljubljana, Slovenia; 2J.Stefan Institute, Jamova 39, Ljubljana, Slovenia; 3Department of Psychology, University of Ljubljana, Ljubljana • Abstract OE-p-03 Preliminary study on possible influence of elemental mercury during pregnancy M. Krsnik2, A.B. Kobal2, M. Horvat3, M. Prezelj2, A. Briski2, D. Gibicar3, C. Knap1 and J. Osredkar2 1Idrija Mercury Mine, Idrija, Slovenia; 2University Medical Centre Ljubljana, Institute of Clinical Chemistry and Biochemistry, Ljubljana, Slovenia; 3Jozef Stefan Institute, Ljubljana, Slovenia • Abstract OE-p-04 Elemental mercury vapour and small nerve fibre function Duska Meh1, Alfred B. Kobal2 1Institute for Rehabilitation and Department for Physical and Rehabilitation Medicine, Medical Faculty Ljubljana, Linhartova 51, 1000 Ljubljana, Slovenia; 2Department of Occupational Medicine, Idrija Mercury Mine, Idrija, Slovenia • Abstract OE-p-05 Biological monitoring of ortho-toluidine in occupational exposure L. Labat1, J. Thomas1, B. Dehon1, L. Humbert1, B. Leleu2, C. Nisse3, M. Lhermitte1 1Laboratoire de Toxicologie et Génopathies, CHRU de Lille, France; 2Sita Agora, Noyelles Gaudolt, France; 3Service de Pathologie Professionnelle et Environnement, CHRU de Lille, France • Abstract OE-p-06 Alteration in the immunotoxicity of LOEL dose of dimethoate on combined exposure with NOEL doses of cypermethrin and amitraz in rats in a subacute experimental system L. Institóris1, I.K. Kecskeméti1, Dóra Kovács1, Anita Lukács2, Andrea Szabó2, Zsuzsanna Lengyel2, A. Papp2 1Dept. Forensic Medicine, Szeged, Hungary; 2Dept. Public Health, Fac. Medicine, Univ. Szeged, Szeged, Hungary • Abstract Top CLINICAL FORENSIC TOXICOLOGY Platform Presentations - Poster Presentations CT-o-01 Alfred Swaine Taylor MD FRS (1806-1880) Robert James Flanagan1 and Katherine Watson2 1Medical Toxicology Unit, Guy's & St Thomas' NHS Trust, London, UK, 2School of Arts & Humanities, Oxford Brookes University, Oxford, UK • Abstract CT-o-02 Toxicological aspects in relation to the drug transporter P- glycoprotein at the blood-brain barrier Kristian Linnet and Thomas B. Ejsing The Dept of Forensic Chemistry, University of Copenhagen, Denmark • Abstract CT-o-03 Biotechnological synthesis of drug metabolites using P450-expressing fission yeast – new perspectives in metabolism studies for 4’methyl-α-pyrrolidinobutyrophenone Frank T. Peters1, Calin-Aurel Dragan2, Markus R. Meyer1, Matthias Bureik2, and Hans H. Maurer1 1Department of Experimental and Clinical Toxicology, Saarland University, Homburg (Saar), Germany; 2PomBioTech, Saarbruecken, Germany • Abstract CT-o-04 Systematic Toxicological Analysis of Xenobiotics – Comparison of the results obtained on patient samples using immunoassays, LC/DAD and LC/MS methods M. Lhermitte1, M. Wood2, L. Humbert1, G. Bondoux3 1Laboratoire de Toxicologie & Génopathies, Hôpital Calmette - CHRU de Lille, Lille Cedex – France; 2Waters Corporation, Atlas Park, Manchester, U.K; 3Waters Corporation, European Headquarters Waters S.A.S., Guyancourt - France • Abstract CT-o-05 Development of a fully automated screening system for the determination of basic compounds in urine by on-line extraction – high performance liquid chromatography with photodiode-array detection Lena Schönberg1,2, Thomas Grobosch2, Dagmar Lampe2 and Charlotte Kloft1,3 1Department of Clinical Pharmacy, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany; 2Berliner Betrieb fuer Zentrale Gesundheitliche Aufgaben (BBGes), Institute of Clinical Toxicology – Clinical Toxicology and Poison Control Centre, Berlin, Germany; 3Department of Clinical Pharmacy, Faculty of Pharmacy, Martin-Luther-Universitaet Halle-Wittenberg, Germany • Abstract CT-o-06 Maternal methadone dose, methadone meconium concentrations, severity of neonatal abstinence syndrome and other birth outcomes Robin E. Choo1, Hendrée E. Jones2, Jennifer R. Schroeder3 and Marilyn A. Huestis1 1Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; 2Center for Addiction and Pregnancy, Johns Hopkins Bayview Medical Center; 3Office of the Clinical Director, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, MD, USA • Abstract CT-o-07 Toxicological analysis and toxicokinetics in an acute fluoxetine and trimipramine intoxication Thomas Grobosch and Dagmar Lampe Berliner Betrieb für Zentrale Gesundheitliche Aufgaben (BBGes), Institute of Toxicology Clinical Toxicology and Poison Control Center Berlin, Berlin, Germany • Abstract CT-o-08 Determination of ergotamine in hair, plasma and urine samples by liquid chromatography - tandem mass spectrometry Donata Favretto, Giampietro Frison, Susanna Vogliardi and Santo Davide Ferrara Forensic Toxicology and Antidoping, University Hospital of Padova, Padova, Italy • Abstract CT-o-09 Within-subject variability of alcohol pharmacokinetic parameters Donald Noel Sims1, Jaimi Burns1 Lisa Yelland2, Amy Salter2 and Jason White3 1Forensic Science SA; 2Department of Public Health, The University of Adelaide; 3Department of Clinical and Experimental Pharmacology, The University of Adelaide • Abstract CT-o-10 Kinetics of ethyl sulfate and ethyl glucuronide after medium dose ethanol Claudia C. Halter1, Volker Auwaerter1, Haiko Schloegl1, Sebastian Dresen1, Friedrich M. Wurst2 and Wolfgang Weinmann1 1Institute of Forensic Medicine, University Hospital, Freiburg, Germany; 2Psychiatric University Clinic Basel, Basel, Switzerland • Abstract CT-o-11 Sensitivity and specificity of ethyl glucuronide in hair as a marker of chronic heavy alcohol use- preliminary results Aldo Polettini, Luca Morini, Cristiana Stramesi and Lucia Politi Department of Legal Medicine & Public Health, University of Pavia, Pavia, Italy • Abstract CT-o-12 Predictive value of CDT (carbohydrate-deficient transferrin) in assessing fitness to drive Raffaele Giorgetti, Lorenzo Luporini, Stefania Pagani, Adriano Tagliabracci Dipartimento di Neuroscienze, Sezione di Medicina Legale, Università Politecnica delle Marche, Ancona, Italy • Abstract Top CLINICAL FORENSIC TOXICOLOGY Poster Presentations - Platform Presentations CT-p-01 The Extent and Mortality of Insecticide Related Acute Poisoning in Upper Egypt Magda H. El-Karadawy1, Soheir A. Mohamed2, Nady S. Aly1, Khaled M. Mohamed1 1Medico-Legal Department, Ministry of Justice, Egypt; 2Forensic Medicine and Toxicology, Faculty of Medicine, South Valley University • Abstract CT-p-02 Effects of Ciprofloxacin on testis apoptosis and sperm parameters in rat Marefat Ghaffari Novin, Mahnaz Heidari, Arash Khaki Reproductive Biotechnology Center, Avesina Research Institute, Tehran, Iran • Abstract CT-p-03 A novel method for Automated Detection and Identification of Toxicological relevant compounds in Urine and Serum samples using a GC/MS/NPD system Bernhard Rothweiler Agilent Technologies, Waldbronn, Germany • Abstract CT-p-04 Successful suicide with oxygen using a facial mask at hospital – A case report P. Mura1, M. Sapanet2, P. Kintz3 1Laboratoire de Toxicologie et Pharmacocinétique, CHU, Poitiers, France; 2Service de Médecine Légale, CHU, Poitiers, France ; 3Laboratoire ChemTox, Illkirch, France • Abstract CT-p-05 Acute Deliberate Organophosphate (Coumaphos) Poisoning With Intermediate Syndrome in a One Year Old Child Kiat, W.K. Toxicology Unit, St. Luke’s Medical Center, Quezon City, Philippines • Abstract CT-p-06 Rapid and selective analysis of nicotine and cotinine in urine by using HPLC-UV with post-column photo-irradiation Jennifer P. Pascali, Federica Bortolotti, Rossella Gottardo, Franco Tagliaro Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, Verona, Italy • Abstract CT-p-07 Citalopram in newborns: A case report Eva Novakova Institute of Forensic Medicine and Toxicology, 1st Medical School and Hospital, Charles University, Prague, Czech Republic • Abstract • Full Text CT-p-08 Analysis of Carbohydrate-Deficient Transferrin (CDT) as a marker of chronic alcohol abuse. Comparative Evaluation of a Commercial Fully Automated Multicapillary Electropherograph with a Single Capillary Electropherograph Giorgia De Paoli, Federica Bortolotti, Jennifer P. Pascali, Franco Tagliaro Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, Verona, Italy • Abstract CT-p-09 A systematic and comprehensive method for general toxicological screening using QTrap LC-UV-MS-MS Simon Elliott1, Frans Schoutsen2, Bénédicte Duretz3 1Regional Laboratory for Toxicology, Birmingham, United Kingdom; 2Applied Biosystems, Warrington, United Kingdom; 3Applied Biosystems, Les Ulis, France • Abstract CT-p-10 Case report: Ethylene glycol poisoning Lovrić M1, Granić P1, Čubrilo-Turek M2, Lalić Z1, Sertić J1 1Clinical Institute of Laboratory Diagnosis, Zagreb University Hospital Center, Zagreb, Croatia; 2Department of Internal Medicine, “Sveti Duh” General Hospital, Zagreb, Croatia • Abstract CT-p-11 Fast HPLC-DAD method for simultaneous phenotyping of CYP2C19 and CYP3A4 through the determination of omeprazole and two of its metabolites in human plasma samples Rafael Linden1, André Arigony Souto2 1Centro Universitário Feevale; 2Pontifícia Universidade Católica do Rio Grande do Sul • Abstract CT-p-12 Forensic Toxicology in South Africa: scope, trends and challenges A. A. Grové1, A.S. Schillack2 , I.J. Fenyvesi3 and M.J. Stewart4 1Department of Health: Forensic Chemistry Laboratory, Private Bag X282, Pretoria 0001, South Africa; 2Department of Health: Forensic Chemistry Laboratory, P. O. Box 668, Woodstock, Cape Town 8000, South Africa; 3Department of Health: Forensic Chemistry Laboratory, P.O. Box 1080, Johannesburg 2000, South Africa; 4Director: Forensic Pathology Services, Department of Health, Private Bag X828, Pretoria 0001, South Africa • Abstract CT-p-13 Platinum levels in various tissues of a patient died 181 days after cisplatin overdose determined by electrospray ionization mass spectrometry Kayoko Minakata, Osamu Suzuki Hamamatsu University School of Medicine, Japan • Abstract • Full Text CT-p-14 Simple screening tests of poisons for clinical and forensic laboratory in Japan Kojiro Kimura Department of Legal Medicine, Hiroshima University, Japan • Abstract CT-p-15 Fulminant liver failure in a patient on carbamazepine and levetiracetam treatment G. Skopp1, H. P. Schmitt2, I. Pedal1 1Institute of Legal and Traffic Medicine, Voss-Str. 2, 69125 Heidelberg, Germany; 2Institute of Pathology, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany • Abstract • Full Text CT-p-16 Difficulties and Pitfalls in Analysis of Benzodiazepines Kateřina Zedníková, Peter Ondra Faculty Hospital, Institute of Forensic Medicine and Medical Law, Hněvotínská 3, 775 09, Olomouc, Czech Republic • Abstract • Full Text CT-p-17 Histopathological Effects of Chronic Opium Dosage on Normal and Diabetic Rats: Effects on the Liver and Kidney Hatem Abdel Monem Ahmed1, Alaa M. Alanwar2, E. H. El Gawish3, Shaaban M. Ahmed4, M. H. Ibrahem5 1Assiut Lab. of Midico-legal Department, Egypt; 2Ministry of Justice, Egypt; 3Assuit Branch, Egypt; 4Zoology Department, Faculty of science, Elmenia University, Egypt • Abstract CT-p-18 Drug-facilitated sexual assault provoked by the victim’s religious beliefs: A rare case report C. Maravelias, M. Stefanidou, A. Dona, S. Athanaselis and Ch. Spiliopoulou Department of Forensic Medicine and Toxicology, University of Athens, Medical School, 75 Mikras Asias street, Goudi, Athens 115 27 Greece • Full Text Top DRUGS OF ABUSE Platform Presentations - Poster Presentations DA-o-01 Identification of human monoamine oxidases A/B and cytochrome P450 2D6 as major enzymes involved in the main metabolic steps of phenethylamine-derived designer drugs (2c-series) Denis S. Theobald and Hans H. Maurer Department of Experimental and Clinical Toxicology, University of Saarland, Homburg (Saar), Germany • Abstract DA-o-02 Designer drug TMA-2: studies on the metabolism including CYP isoform dependency and on the toxicological detection A.H. Ewald1, G. Fritschi2, and H.H. Maurer1 1Department of Experimental and Clinical Toxicology, University of Saarland, Homburg (Saar); 2Hessisches Landeskriminalamt, Wiesbaden, Germany • Abstract DA-o-03 Suspension Bead Array (SBA) technology as a presumptive tool in testing for amphetamine- type substances and designer analogues Luigino Apollonio1, Jennelle Kyd1, Ian Whittall2, Dennis Pianca2, William Maher1 1National Centre for Forensic Studies, University of Canberra, Bruce ACT, Australia; 2Department of Toxicology and Forensic Chemistry, ACT Government Analytical Laboratory, Weston Creek ACT, Australia • Abstract DA-o-04 Urinary elimination of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (CTHC) after its intravenous application L. Dietz1, A. Glaz-Sandberg2, H. Nguyen3, G. Mikus2 und R. Aderjan1 1Institute of Legal Medicine and Traffic Medicine; 2Dept of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology; 3University Hospital Pharmacy, University of Heidelberg, Heidelberg Germany, • Abstract DA-o-05 GHC serum concentrations and pitfalls of interpretation Susanne Vogt, Maren Hermanns-Clausen, Jessica Traber, Wolfgang Weinmann Institute of Forensic Medicine, University Hospital Freiburg, Freiburg, Germany • Abstract DA-o-06 Further evidence of in vitro production of endogenous GHB in urine samples Marc LeBeau, Madeline Montgomery, Cynthia Morris-Kukoski, Jason Schaff, Anna Deakin FBI Laboratory, Chemistry Unit, Quantico, VA, USA • Abstract DA-o-07 Internet monitoring: Getting high by pharmaceutical tampering Edward J. Cone1, Sidney Schnoll1, John Pinney1, Jack E. Henningfield1, Reginald V. Fant, Bruce A. Goldberger2 and Chris W. Chronister2 1Pinney Associates, Bethesda, MD, USA; 2University of Florida College of Medicine, Gainesville, FL, USA • Abstract DA-o-08 An unusual case of DFSA using aromatic solvents María A. Martínez1 and Salomé Ballesteros2 1Chemistry Department, 2Spanish Poison Control Center, National Institute of Toxicology and Forensic Sciences, Ministry of Justice, Madrid, Spain • Abstract DA-o-09 Compliance testing in methadone substitution therapy: evaluation of CEDIA EDDP taking account of methadone dose, urinary pH, creatinine and CEDIA Sample Check Michael Boettcher1, Christian Jellinek2, Olof Beck3 1Arztpraxis für Medizinische Mikrobiologie und Labordiagnostik, Dessau, Germany; 2Ambulanz für Integrierte Drogenhilfe Neukoelln, Berlin, Germany; 3Department of Clinical Pharmacology, Karolinska Institute, Stockholm, Sweden • Abstract DA-o-10 A validation of meconin as an indicator for illicit opiate use John H. Galloway, A. Robert W. Forrest and Stephen R. Morley Department of Clinical Chemistry, Royal Hallamshire Hospital, Sheffield, Great Britain. • Abstract DA-o-11 Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake - Use as adulterant of cocaine resulting in drug – drug interactions? Roland F. Staack, Liane D. Paul, Dagmar Schmid, Gabriele Roider, Burkhard Rolf Institute of Forensic Medicine, University of Munich, Germany • Abstract DA-o-12 Heroin drugged drivers: Role of morphine and morphine-6-glucuronide in clinical impairment Liliana C. Bachs, Gudrun Høiseth, Svetlana Skurtveit and Jørg Mørland Norwegian Institute of Public Health, Oslo, Norway • Abstract Top DRUGS OF ABUSE Poster Presentations - Platform Presentations DA-p-01 Driving under the influence in Greece: A seven year survey (1998-2004) Papadodima S., Athanaselis S., Maravelias K., Dona A., Stefanidou M., Papoutsis, J., Spiliopoulou C. Dept.of Forensic Medicine and Toxicology, School of Medicine, University of Athens, Greece • Abstract • Full Text DA-p-02 Elimination of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (CTHC) and formation and elimination of its acyl-glucuronide (CTHC–Glu) in serum after intravenous application of 5 mg R. Aderjan1, L. Dietz1, A. Glaz-Sandberg2, H. Nguyen3, G. Mikus2 1Institute of Legal Medicine and Traffic Medicine; 2Dept of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology; 3University Hospital Pharmacy, University of Heidelberg, Germany • Abstract DA-p-03 Quantitative determination of major cutting agents in cocaine samples seized in Slovenia in the period from May 2004 to November 2005 Tomaž Gostič Ministry of the Interior, Forensic Research Center, Ljubljana, Slovenia • Abstract DA-p-04 Interactions among the components in amphetamine-type stimulant tablets in human intestinal Caco-2 cells and in oral administration to rats Kenji Kuwayama1, Kenji Tsujikawa1, Hajime Miyaguchi1, Tatsuyuki Kanamori1, Yuko Iwata1, Hiroyuki Inoue1, Tohru Kishi1, Seiji Miyauchi2, Naoki Kamo1 1National Research Institute of Police Science; 2Laboratory of Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University • Abstract DA-p-05 Characterization of Volatile Components of Marijuana and Hashish (Cannabis Sativa L.) Yuko T. Iwata, Hiroyuki Inoue, Kenji Kuwayama, Tatsuyuki Kanamori, Kenji Tsujikawa, Hajime Miyaguchi and Tohru Kishi National Research Institute of Police Science, 6-3-1, Kashiwanoha, 277-0882, Kashiwa, Japan, Chiba • Abstract DA-p-06 Analysis of Ketamine & Norketamine in Urine by Automatic Solid-Phase Extraction (SPE) and Positive ion chemical ionization–gas chromatography-mass spectrometry (PCI-GC-MS) Eunmi Kim, Juseon Lee, Sangkil Choi, Miae Lim and Heesun Chung National Institute of Scientific Investigation, Korea • Abstract DA-p-07 Evaluation of a homogenous urine immunoassay for the determination of methadone in serum samples Michael Boettcher, Stefan Lierheimer Arztpraxis für Medizinische Mikrobiologie und Labordiagnostik, Dessau, Germany • Abstract DA-p-08 GC/MS Analysis of Ketamine in urine of sexual assault victims Shanlin Fu, John Lewis PaLMS, Northern Sydney Central Coast Area Health, NSW, Australia • Abstract DA-p-09 A screening method using LC-MS/MS for illicit drugs in plasma and postmortem blood Akgür S.A., Dolma C., Ertaş H., Moral A.R. Ege University Poison Research and Application Center, Bornova, 35100, İzmir, Turkey • Abstract DA-p-10 Validation of the new CEDIA THCplus urine immunoassay M.Boettcher1, A.Peschel1, W.Haase2 1Arztpraxis für Medizinische Mikrobiologie und Labordiagnostik, Dessau, Germany; 2MEDILYS, Zentrallabor Klinikum Nord, Hamburg, Germany • Abstract DA-p-11 Estrogenic Effect of Marijuana Smoke Condensate Sooyeun Lee1,2, Heesun Chung1, Seungmin Oh2, Taejung Kwon1, Chunsam Kim1, Sangki Lee1, Kyuhyuck Chung2 1National Institute of Scientific Investigation, Seoul 158-707, Korea; 2Sungkyunkwan University, Gyeonggi-do 440-746, Korea • Abstract DA-p-12 Detection of Δ9-Tetrahydrocannabinolic acid in human urine and human blood serum by LC/MS/MS and GC/MS Julia Jung, Juergen Kempf, Wolfgang Weinmann Institute of Legal Medicine, Forensic Toxicology, University Hospital, Freiburg • Abstract DA-p-13 Distribution characteristics of 2,5-dimethoxy-4-bromoamphetamine (DOB) in rats after oral and subcutaneous administration Katerina Berankova, Marie Balikova Institute of Forensic Medicine and Toxicology, 1st Medical Faculty, Charles University in Prague • Abstract DA-p-14 Adulterants in Heroin Seized in the Canton Bern Switzerland Werner Bernhard, Alain Broillet, Franziska Luginbühl, Priska Regenscheit Institute of Legal Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland • Abstract • Full Text DA-p-15 Combined abuse of liquid ecstasy and amphetamines in duid cases Wolfgang Weinmann, Sebastian Dresen, Jürgen Kempf Institute of Forensic Medicine, University Hospital Freiburg, Albertstr. 9, D 79104 Freiburg, Germany • Abstract DA-p-16 Analysis of certain cannabinoid metabolites in urine samples from Hungary by GC/MS after alkaline and enzymatic hydrolysis Előd Hidvégi1, Edit Penczi1, Zsuzsa Hideg1, Douwe de Boer2, Gábor Somogyi1 1National Institute of Forensic Toxicology, Budapest, Hungary; 2Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, The Netherlands • Abstract DA-p-17 Quantification of cocaine and benzoylecgonine in wastewater by gas chromatography-mass spectrometry: mapping cocaine abuse in the Belgian university city of Leuven Dieter Waumans, Steven Pauwels, Noël Bruneel, Jan Tytgat Laboratory of Toxicology, Campus Gasthuisberg, O&N2, Herestraat 49, P.O. Box 922, B-3000 Leuven, Belgium • Abstract DA-p-18 Use of pectin as a drug screen adulterant and its detection by Intect® 7 Raphael C. Wong, Beckie Wong, Olivia Chan, Chan Patel Branan Medical Corporation • Abstract DA-p-19 Drug Screening in Serum Samples with the Dade Behring Viva-E™ System Gertrud Rochholz, Agnes Heinemann, Cornelia Franzelius Institut für Rechtsmedizin, Universitätsklinikum Schleswig-Holstein, Germany • Abstract DA-p-20 Chemical additives of street heroin in Cairo Dr. Abd El- Aziz Ghanim , Amal Abd El – Salam El – Bakary and Alaa Ali Hassan Forensic Medicine and Clinical Toxicology Department, Mansoura University and Medicolegal Administration, Ministry of Justice, Egypt • Abstract DA-p-21 Phenacetin is coming back! Marc Augsburger, Aurélie Bourdon, Frank Sporkert, and Patrice Mangin Institut Universitaire de Médecine Légale, Rue du Bugnon 21, 1005 Lausanne, Switzerland • Abstract DA-p-22 VIAGRA®, CIALIS® and LEVITRA® - the analysis of original and counterfeit tablets used to treat erectile dysfunction Dariusz Zuba Institute of Forensic Research, Westerplatte 9, 31033 Krakow, Poland • Abstract DA-p-23 LSD, Magic Mushrooms and Peyote in Switzerland Werner Bernhard, Priska Regenscheit Institute of Legal Medicine, University of Bern, Buehlstrasse 20, 3012 Bern, Switzerland • Abstract Top TOXINS & HERBALS & VENOMS TH-p-01 Studies on the cause of an encephalopathy which took place in the limited areas in Japan 2004: a possibility of poisoning by cyanide being contained in a kind of mushroom Kunio Gonmori1, Kayoko Minakata1, Kanako Watanabe1, Shigeru Sato2, Itaru Toyoshima2, Noriyuki Matsumoto3 and Osamu Suzuki1 1Department of Legal Medicine, Hamamatsu University School of Medicine, Japan; 2Investigative Committee of Acute Encephalopathy in Akita Prefecture, Japan; 3Niigata Prefectural Forest Research Institute, Japan • Abstract • Full Text TH-p-02 UPLC-MS/MS findings in a fatality involving massive ingestion of yew (Taxus spp.) leaves and berries Carole Jamey1, Nadia Ihadadène2, Françoise Flesch2, Chaouki Mezher3, Esther Szwarc1, Bertrand Ludes1, Antoine Tracqui1 1Laboratoire de Toxicologie, Institut de Médecine Légale, 11 rue Humann, F-67085 Strasbourg, France; 2Centre Antipoison, Hôpitaux Universitaires de Strasbourg, 1 place de l'Hôpital BP 426, F-67091 Strasbourg, France; 3Service de Réanimation, Centre Hospitalier, 2 rue du Docteur-Flamand, F-25200 Montbéliard, France • Abstract TH-p-03 Analysis of herbal medicines with risks of abuse F.S. Romolo1, M.C. Rotolo1, M. Pellegrini2, F. Rosati1 1Legal Medicine Department, Università degli Studi di Roma “La Sapienza”, Viale Regina Elena 336 - 00161 Rome, Italy; 2Clinical Biochemistry Department, Istituto Superiore di Sanità, Viale Regina Elena 299 - 00161 Rome, Italy • Abstract TH-p-04 Concentrations of tetrodotoxin and aconitine using a column-switching LC-ESI-MS method in mouse serum Makiko Hayashida, Makoto Nihira, Youkichi Ohno Department of Legal Medicine; Nippon Medical School; Bunkyo-Ku, Tokyo 113-8602, Japan • Abstract Top SYMPOSIUM: Medicinal Drugs and Human Performance MD-01 Drugs and driving – Introduction Majda Zorec Karlovšek Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Slovenia • Abstract MD-02 Measurement and Interpretation of the Central Effects of Drugs: Implications to Behavioural and Forensic Toxicology Julia Boyle School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, UK • Presentation MD-03 Risk of involvement in traffic accidents associated with medicinal drugs Olaf H. Drummer Forensic and Scientific Services, Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University, Melbourne, Australia • Full Text MD-04 Medicinal drugs and traffic safety - the Norwegian experience Asbjørg Christophersen Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway • Presentation MD-05 Medicinal drugs and traffic safety - the Spanish experience F. Javier Álvarez Department of Pharmacology, Institute for Alcohol and Drug Studies, Faculty of Medicine, University of Valladolid, Spain • Full Text MD-06 Medicinal drugs and traffic safety – European DRUID project F. Javier Álvarez Department of Pharmacology, Institute for Alcohol and Drug Studies, Faculty of Medicine, University of Valladolid, Spain • Full Text MD-07 The experience with the categorisation of medicinal drugs in Belgium Alain G. Verstraete Laboratory of Clinical Biology–Toxicology, Ghent University Hospital, and Department of Clinical Biology, Microbiology and Immunology, Ghent University, Belgium • Abstract MD-08 The handling and statistics of Suspected Drugs and Driving Cases in Finland Sirpa Mykkänen and Pirjo Lillsunde National Public Health Institute, Laboratory of Alcohol and Substance Abuse, Helsinki, Finland • Full Text MD-09 Serving Patient Needs: Marketing Authorization Procedures and Pharmacovigilance Stanislav Primožič Ministry of health, Agency of medicinal products and Medicinal devices of the Republic of Slovenia, Ljubljana, Slovenia • Presentation MD-10 Evaluation of Medicines Affecting Human Performance Lovro Stanovnik Institute of Pharmacology, Medical Faculty , University of Ljubljana, Slovenia • Full Text MD-11 Medicinal drug use in Slovenia Jurij Fürst Health Assurance Institute of Slovenia (ZZZS), Ljubljana, Slovenia • Full Text MD-12 The patern ob benzodiazepines prescribing among Slovenian General Practitioners Igor Švab, Marko Kolšek, Nena Kopčavar Guček Department of Family Medicine, Medical School, University of Ljubljana, Ljubljana, Slovenia • Abstract • Full Text MD-13 Ask your Pharmacist Frankič Darja Slovenian Chamber of Pharmacy, Ljubljana, Slovenia • Full Text MD-14 Drivers attitudes to medicinal drugs and possibilities of preventive activities Bojan Žlender Slovenian Road Safety Council, Ljubljana, Slovenia • Presentation Top

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